The effects of OxyShred Ultra Concentration on metabolic, hemodynamic, and mood outcomes

A randomized, double-blind, placebo-controlled crossover trial examining acute effects of the thermogenic supplement OxyShred on resting energy expenditure, cardiovascular markers, and subjective mood states.

Journal of the International Society of Sports Nutrition (2023) · DOI: 10.1080/15502783.2023.2185538

Quick Facts

Participants: 23 healthy female college students, ages 18–40, BMI 25–32.5

Design: Randomized, double-blind, placebo-controlled crossover

Testing: Baseline, then 30, 60, 120, and 180 minutes post-ingestion

Overview

Purpose

Determine whether a thermogenic supplement alters metabolic rate, hemodynamic responses, and mood states.

Intervention

One serving of OxyShred (containing caffeine, carnitine, and plant extracts) versus placebo.

Headline Result

Resting energy expenditure increased for up to three hours without adverse hemodynamic responses.

Study Design

Participants

Healthy female college students (n=23), moderate caffeine consumers, BMI 25–32.5.

Protocol

Baseline testing followed by supplement or placebo ingestion, with repeat measures at 30, 60, 120, and 180 minutes.

Crossover

Each participant completed both conditions, separated by a minimum seven-day washout period.

Baseline 30 min 60 min 120 min 180 min Measures: REE, BP, HR, Blood Markers, Mood

Key Findings

Resting Energy Expenditure

REE increased following supplementation, with mean increases of approximately 121–166 kcal/day.

Hemodynamics

Systolic blood pressure rose modestly (3–4 mmHg) and remained within normal clinical ranges.

Blood Markers

Free fatty acids increased, indicating enhanced lipid mobilization during the test window.

Mood

Subjective fatigue decreased significantly; other mood measures were unchanged.

What the Results Mean in Practice

Energy Use

Temporary increases in calorie expenditure occurred. This demonstrates an acute metabolic effect but does not confirm long-term weight loss.

Cardiovascular Safety

Mild stimulant-related effects were observed without adverse cardiovascular responses in this healthy population.

Subjective Experience

Participants reported feeling less fatigued following supplementation, which correlates with the caffeine content.

Figures

Overview of testing sessions
Figure 1. Overview of testing sessions.
Resting energy expenditure over time
Figure 2. Resting energy expenditure over time.

Supplement Notes

Ingredient Matrix

The proprietary blend includes acetyl L-carnitine, Garcinia cambogia extract, CLA, grapefruit seed extract, raspberry ketones, green coffee bean extract, bitter orange, olive leaf extract, guggul extract, and chromium picolinate.

  • Caffeine & Bitter Orange: Stimulants typically used for alertness and energy.
  • Garcinia & CLA: Commonly marketed for appetite control and body composition.
  • Study Limitations: The study evaluated the multi-ingredient formula, not individual ingredients.